Yes, business travel in Hong Kong can be safe with the right security plan. Crime levels are relatively low, however pickpocketing and theft do happen. Hong Kong has recently experienced some political instability resulting in protests and civil unrest. Many protests are peaceful, however can turn violent quite quickly. There is severe risk of travel being disrupted, including public transport and road travel if a protest breaks out.
Business travelers should consider secure ground transportation to avoid disruptions and risk to personal safety.